:root{--ink:#102e50;--blue:#2459a6;--muted:#53647a;--line:#d8e1ec;--wash:#f3f6fa;--white:#fff}*{box-sizing:border-box}html{scroll-behavior:smooth;scroll-padding-top:6rem}body{margin:0;color:var(--ink);background:white;font:1rem/1.7 Arial,Helvetica,sans-serif}a{color:inherit;text-underline-offset:4px}button{font:inherit}h1,h2,h3,p{margin:0}h1,h2,h3{line-height:1.12;letter-spacing:-.045em}h1{font-size:clamp(2.7rem,4.5vw,4.6rem);font-weight:550;max-width:820px}h1 em{font-style:normal;color:var(--blue)}h2{font-size:clamp(2.3rem,3.8vw,3.5rem);font-weight:500}h3{font-size:1.45rem;font-weight:600;letter-spacing:-.025em}p{color:var(--muted)}.wrap{width:min(1240px,calc(100% - 96px));margin:auto}.skip{position:absolute;top:-90px;left:20px;background:var(--ink);color:white;padding:12px;z-index:20}.skip:focus{top:10px}header{display:flex;align-items:center;justify-content:space-between;padding:22px 48px;border-bottom:1px solid 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h2{font-size:1.75rem;letter-spacing:-.025em}.principle{display:flex;gap:18px;padding-top:24px;align-items:flex-start}.principle>span{font-size:.875rem;color:var(--blue);font-weight:700;line-height:1.7}.principle p{font-size:.95rem;line-height:1.5}.principle strong{display:block;color:var(--ink);margin-bottom:6px}.panel-foot{margin-top:27px;padding-top:20px;border-top:1px solid var(--line);font-size:.875rem;line-height:1.6;color:var(--muted)}.status-band{background:var(--ink);color:white}.status-band .wrap{display:grid;grid-template-columns:140px 1fr 210px;gap:35px;align-items:center;padding-top:24px;padding-bottom:24px;font-size:.875rem}.status-band p{color:#d6e1ef;line-height:1.6}.status-band a{font-weight:600}.section{padding-top:90px;padding-bottom:90px}.section-heading{display:grid;grid-template-columns:1fr 1fr;gap:20px 90px;margin-bottom:48px;align-items:end}.section-heading 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0;letter-spacing:-.02em}.doc-summary{display:block;font-size:.95rem;color:var(--muted)}.doc-action{font-size:.9rem;font-weight:600;color:var(--blue)}.document:hover strong{text-decoration:underline}.archive{margin-top:25px;font-size:.95rem}.archive summary{cursor:pointer;font-weight:600;padding:10px 0}.archive div{display:flex;flex-wrap:wrap;gap:15px 30px;padding:14px 0}.governance-grid{display:grid;grid-template-columns:repeat(4,1fr);gap:27px}.governance-grid article{border-top:2px solid var(--blue);padding-top:23px}.governance-grid h3{font-size:1.2rem;margin-bottom:15px}.governance-grid p{font-size:.9rem}.contact-section{background:var(--ink);color:white;padding:75px 0}.contact-layout{display:grid;grid-template-columns:1.3fr 1fr;gap:100px}.contact-section .eyebrow{color:#a8c6f0}.contact-section p{color:#d6e1ef;max-width:600px;margin:24px 0}.contact-section aside{padding-left:38px;border-left:1px solid #526a86}.contact-section aside h3{font-size:1.4rem}.contact-section ul{padding-left:20px;color:#d6e1ef;font-size:.95rem;margin:23px 0}.contact-section li{margin:9px 0}.contact-section aside a{overflow-wrap:anywhere}.contact-section aside p{font-size:.875rem}.light{background:white;color:var(--ink)}footer{padding-top:30px;padding-bottom:30px;display:grid;grid-template-columns:260px 1fr 130px;gap:35px;align-items:start}.footer-brand{text-decoration:none;font-weight:700;font-size:.95rem}footer p{font-size:.8rem;line-height:1.6}footer>a:last-child{font-size:.85rem}a:focus-visible,button:focus-visible,summary:focus-visible{outline:3px solid #6399e6;outline-offset:5px}
@media(max-width:1100px){header{padding:20px 28px}nav{gap:14px}.wrap{width:calc(100% - 56px)}.hero{gap:35px}.hero-panel{padding:25px}.hero{padding-top:60px;padding-bottom:60px}.keyspot{grid-template-columns:140px 1fr}.keyspot .button{grid-column:2}.governance-grid{grid-template-columns:1fr 1fr}.contact-layout{gap:50px}.section-heading{gap:20px 40px}.status-band .wrap{grid-template-columns:120px 1fr}.status-band a{grid-column:2}.framework-layout{gap:35px}footer{grid-template-columns:220px 1fr}footer>a:last-child{grid-column:2}}
@media(max-width:760px){html{scroll-padding-top:1rem}header{padding:18px 22px;position:relative;flex-wrap:wrap}.monogram{font-size:2rem}.brand-name{font-size:.8rem}.menu-button{display:block;background:white;border:1px solid var(--line);border-radius:3px;padding:7px 13px;font-size:.9rem;color:var(--ink)}nav{display:none;width:100%;align-items:flex-start;gap:0}nav.open{display:flex;flex-direction:column}nav a{padding:10px 0;width:100%}.nav-contact{border:0}.wrap{width:calc(100% - 44px)}.hero{grid-template-columns:1fr;gap:35px;padding:45px 0}.eyebrow{font-size:.75rem;letter-spacing:.08em;margin-bottom:18px}h1{font-size:2.75rem}.intro{font-size:1.05rem;margin-top:22px}.actions{flex-direction:column}.actions .button{width:100%}.hero-panel{padding:27px}.hero-panel h2{font-size:1.8rem}.status-band .wrap{display:block;padding:25px 0}.status-band p{margin:10px 0}.section{padding:55px 0}.section-heading{display:block;margin-bottom:30px}.section-heading .eyebrow{margin-bottom:16px}.section-heading>p:last-child{margin-top:22px;font-size:1rem}h2{font-size:2.5rem}.framework-layout{grid-template-columns:1fr;gap:35px}.definition{padding-left:22px}.definition h3{font-size:1.7rem}.framework-grid{gap:25px}.framework-grid h3{font-size:1.2rem}.framework-grid p{font-size:.9rem}.cards{grid-template-columns:1fr}.cards article{padding:25px}.keyspot{display:block;padding-top:27px}.keyspot p{margin:18px 0}.evidence-layout{grid-template-columns:1fr;gap:32px}.evidence-lead{padding:27px}.evidence-lead h3{font-size:1.85rem}.research-note{display:block}.research-note p{margin-top:13px}.document{grid-template-columns:40px 1fr;gap:17px;padding:23px 0}.doc-icon{width:40px;height:52px}.document strong{font-size:1.15rem}.doc-action{grid-column:2}.doc-summary{font-size:.9rem}.archive div{flex-direction:column;gap:15px}.governance-grid{grid-template-columns:1fr;gap:26px}.governance-grid h3{font-size:1.3rem}.governance-grid p{font-size:.95rem}.contact-section{padding:55px 0}.contact-layout{grid-template-columns:1fr;gap:38px}.contact-section aside{padding-left:0;padding-top:27px;border-left:0;border-top:1px solid #526a86}footer{display:block}footer p{margin:16px 0}.button{white-space:normal}}
@media(prefers-reduced-motion:reduce){html{scroll-behavior:auto}.button{transition:none}.button:hover{transform:none}}

/* Institutional publication identity */
:root{--ink:#142c43;--blue:#174b77;--muted:#465565;--line:#cdd5dd;--wash:#f4f6f8}
.publisher-bar{background:var(--ink);color:white;font-size:.875rem;border-bottom:4px solid #397aa4}.publisher-bar .wrap{display:flex;justify-content:space-between;gap:20px;padding-top:11px;padding-bottom:11px}.publisher-bar span:first-child{font-weight:700}
header{padding-top:25px;padding-bottom:25px}.brand-name{font-weight:700}.monogram{font-size:2.6rem}.nav-contact{border-radius:0}.breadcrumb{font-size:.875rem;color:var(--muted);margin-bottom:30px}.hero{padding-top:48px;padding-bottom:55px;gap:65px;align-items:start}.hero .eyebrow{margin-bottom:16px}h1{font-size:clamp(2.65rem,4.4vw,4.25rem);font-weight:700;letter-spacing:-.035em;line-height:1.08}.title-mark{font-size:.4em;vertical-align:super;letter-spacing:0}.hero-subtitle{font-size:1.45rem;color:var(--ink);line-height:1.4;font-weight:500;margin:24px 0 0;max-width:630px}.intro{font-size:1.1rem;margin-top:21px}.button{border-radius:0;transition:background .15s}.button:hover{transform:none}.publication-meta{display:grid;grid-template-columns:1fr 1fr;gap:18px 25px;margin-top:33px;padding-top:22px;border-top:1px solid var(--line);font-size:.875rem}.publication-meta div:last-child{grid-column:1/-1}.publication-meta span{display:block;color:var(--muted)}.publication-meta strong{display:block;margin-top:4px}.hero-panel{background:#f4f6f8;border-top:5px solid var(--ink);padding:30px}.hero-panel h2{font-size:1.5rem;font-weight:700}.principle{padding-top:20px}.contents-nav{display:flex;flex-direction:column;align-items:start;gap:8px;margin-top:25px;padding-top:21px;border-top:1px solid var(--line)}.contents-nav strong{font-size:1rem;margin-bottom:5px}.contents-nav a{font-weight:400;font-size:.875rem;text-decoration:underline}.status-band{background:#eaf0f5;color:var(--ink);border-block:1px solid var(--line)}.status-band p{color:var(--muted)}.status-band a{color:var(--blue)}.section{padding-top:72px;padding-bottom:72px}.section+.section{border-top:1px solid var(--line)}h2{font-size:clamp(2rem,3vw,2.8rem);font-weight:650;line-height:1.15;letter-spacing:-.025em}.section-heading .eyebrow{font-size:.75rem}.section-heading>p:last-child{font-size:1rem}.cards article{border:0;border-top:3px solid var(--ink);background:white}.evidence-lead{background:#f0f4f7;color:var(--ink);border-left:4px solid var(--blue)}.evidence-lead .eyebrow{color:var(--blue)}.evidence-lead p{color:var(--muted)}.evidence-lead h3{font-size:1.8rem}.evidence-lead .button{border-color:var(--ink)}.document{background:white;padding:25px; margin-bottom:0;border:1px solid var(--line);border-bottom:0}.document:last-child{border-bottom:1px solid var(--line)}.doc-icon{border:0;background:var(--wash);font-size:1rem}.doc-action{text-decoration:underline;text-underline-offset:4px}.governance-grid{gap:30px}.governance-grid article{border-top:1px solid var(--line)}.contact-section h2{font-size:clamp(2rem,3vw,2.8rem)}footer{border-top:1px solid var(--line)}
@media(max-width:760px){.publisher-bar .wrap{font-size:.75rem;align-items:center;padding-top:10px;padding-bottom:10px;gap:15px}.publisher-bar span:last-child{max-width:145px;text-align:right;line-height:1.4}header{padding:20px 22px}.monogram{font-size:2.2rem}.hero{padding-top:30px;padding-bottom:40px;gap:30px}.breadcrumb{font-size:.8rem;line-height:1.5;margin-bottom:25px}h1{font-size:2.75rem}.hero-subtitle{font-size:1.2rem;margin-top:22px}.intro{font-size:1rem}.publication-meta{gap:18px;font-size:.8rem}.hero-panel{padding:25px}.contents-nav{display:flex;width:auto}.contents-nav a{padding:0;width:auto}.section{padding:48px 0}.section-heading h2{font-size:2.25rem}.document{padding:20px 16px}.contact-section{padding:50px 0}.contact-section h2{font-size:2.25rem}}

/* Supplied brand identities */
.brand .dst-logo{display:block;width:278px;height:auto;max-width:100%;object-fit:contain}.brand{flex-shrink:0}.keyspot-identity{display:flex;align-items:center;gap:18px}.keyspot-logo{display:block;width:108px;height:108px;object-fit:contain;background:#fff}.keyspot-identity .eyebrow{margin-bottom:8px}@media(max-width:1100px){.brand .dst-logo{width:240px}.keyspot-identity{gap:12px}}@media(max-width:760px){.brand .dst-logo{width:210px}.keyspot-logo{width:88px;height:88px}.keyspot-identity{margin-bottom:12px}}

/* Framework reader resources */
.start-here{padding-top:48px;padding-bottom:48px;border-bottom:1px solid var(--line)}.start-here h2{font-size:28px;margin:0 0 24px}.reader-routes{display:grid;grid-template-columns:repeat(3,1fr);gap:18px}.reader-routes a{display:block;padding:22px;border:1px solid #cdd5dd;border-top:3px solid #174b77;text-decoration:none;background:#fff}.reader-routes strong{display:block;font-size:19px;margin-bottom:10px;color:#174b77}.reader-routes span{color:#465565;line-height:1.55}.reader-routes a:hover{background:#f4f6f8}.review-steps{counter-reset:review;list-style:none;padding:0;max-width:850px;margin:0 0 28px}.review-steps li{counter-increment:review;display:flex;gap:24px;padding:22px 0;border-top:1px solid #cdd5dd}.review-steps li:before{content:counter(review);font-weight:700;font-size:20px;flex:0 0 38px;width:38px;height:38px;background:#e9eef3;color:#142c43;display:grid;place-items:center}.review-steps h3{margin-top:0;font-size:22px}.review-steps p{margin-bottom:0;max-width:72ch}.small-note{font-size:14px;max-width:72ch;color:#465565}.evidence-register{margin-top:40px}.table-scroll{overflow-x:auto}table{width:100%;border-collapse:collapse;line-height:1.6;font-size:16px}caption{text-align:left;color:#465565;padding:8px 0 16px}th,td{text-align:left;padding:18px;vertical-align:top;border-bottom:1px solid #cdd5dd}thead th{background:#e9eef3}tbody th{width:27%}.governance-feedback{padding:28px;margin-top:28px;background:#f4f6f8;border-left:3px solid #174b77}.faq-list details{border-top:1px solid #cdd5dd;padding:20px 0}.faq-list details:last-child{border-bottom:1px solid #cdd5dd}.faq-list summary{font-size:20px;font-weight:700;cursor:pointer;color:#174b77}.faq-list details p{max-width:78ch;margin-top:18px}.terms{margin-top:40px}.terms dl{display:grid;grid-template-columns:repeat(3,1fr);gap:24px}.terms dt{font-weight:700;margin-bottom:10px}.terms dd{margin:0;color:#465565;line-height:1.6}@media(max-width:760px){.reader-routes,.terms dl{grid-template-columns:1fr}.review-steps li{gap:16px}table{min-width:640px}.start-here{padding-top:32px;padding-bottom:32px}.governance-feedback{padding:20px}}@media print{header,.publisher-bar,.menu-button,.contact-section{display:none}.section{padding:24px 0}.reader-routes,.terms dl{grid-template-columns:1fr}.hero{display:block}.hero-panel{display:none}a{color:#142c43}.table-scroll{overflow:visible}}

.trial-statement,.independent-context{margin-top:32px;padding:28px;border:1px solid #cdd5dd}.trial-statement{border-left:4px solid #174b77}.independent-context li{margin-bottom:16px;line-height:1.65}.document-status{padding:20px;background:#e9eef3;border-left:3px solid #174b77;line-height:1.65}@media(max-width:760px){.trial-statement,.independent-context{padding:20px}}

/* Institutional review improvements */
.keyspot{grid-template-columns:minmax(270px,1fr) minmax(0,2fr);gap:28px}.keyspot .button{grid-column:2;justify-self:start}.keyspot-identity>div{min-width:0}.reference-request{background:#fff;border:1px solid var(--line);padding:30px}.reference-request p{margin:18px 0}.contact-section form{margin-top:28px;max-width:600px}.contact-section label{display:block;font-weight:700;margin:18px 0 8px}.contact-section input,.contact-section textarea{width:100%;font:inherit;color:var(--ink);background:#fff;border:2px solid #cdd5dd;padding:12px;border-radius:2px}.contact-section form button{cursor:pointer;margin-top:18px}.contact-section input:focus-visible,.contact-section textarea:focus-visible{outline:3px solid #a8c6f0;outline-offset:3px}@media(max-width:900px){.keyspot{grid-template-columns:1fr}.keyspot .button{grid-column:1}.keyspot-identity{max-width:100%}}